Friday, February 24, 2012

It has proven efficacy, especially in prevention

Oral bisphosphonates


about bad absorbed, and therefore must take on an empty stomach without food or drink


be for the next 30 minutes. They



related and


is sometimes poorly tolerated, weekly or monthly


administration (depending on the preparation) decreases likelihood of esophagitis


, and is now standard. Although intermittent >> << dosage of intravenous formulations such as zolendronate avoid dental problems >> << tolerance, these agents are involved at higher rates in


rare but unpleasant disease called the mouth. For this reason, oral bisphosphonates are


, probably better, and destination advice currently recommends that any


correct dental work will be carried to the


treatment. Recently


(Forteo,


remnants of 134) have shown that effective for osteoporosis >>. << It acts as a hormone parathyroid glands, stimulates osteoblasts


, thus increasing their activity. It is used mainly for


patients with established osteoporosis (who had broken


), have especially low IPC or more risk factors for fractures >> << or can not tolerate oral bisphosphonates. This


in daily injections using a pen-type injection device. Teriparatide only licensed for treatment if bisphosphonates


fail or are contraindicated (however, it differs from country to country and


do not need FDA in the U.S.. However, patients with


previous radiation therapy or Paget's disease, or younger patients


avoid this product). Oral


an alternative oral treatment, belonging to the class >> << medicines called "dual action bone agents" (DABAS) it


manufacturer. It has proven efficacy, especially in the prevention of vertebral fractures


. In laboratory experiments, strontium ranelate


, noted to stimulate proliferation of osteoblasts, << and >> preventing lasix 180 mg the spread of osteoclasts. .


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